School of Chemistry | Faculty of Science | The University of Sydney
Periodic Table (PDF) | Useful Data | Useful Formulas | Link to RSS feed | Link to Twitter site | Link to Facebook page | Bookmark and Share

CHEM1902 - Syllabus


Chemistry 1B (Advanced)


The order of topics presented here is essentially the order of presentation in the lecture course, although individual lecturers may make some variations from this. Some topics span more than one week.

Jump to week <1> <2> <3> <4> <5> <6> <7> <8> <9> <10> <11> <12> <13>


Week

Topics covered

1

Representations of Molecular Structure
- revise VSEPR, bonding and shape
- shape and hybridisation for alkanes, alkenes and alkynes
- stick notation
- functional groups and nomenclature

Alkanes
- constitutional isomers
- conformational isomers
- cis/trans isomers of cyclic alkanes
2

Structural Determination
- mass spectrometry
- infrared spectroscopy
- UV-visible spectroscopy
- 1H & 13C NMR spectroscopy
- MRI and medical applications
- problem solving exercises
3
Alkenes
- p-bonds and structure
- E/Z isomers
- addition reactions, mechanism of electrophilic addition
- Markovnikov's rule: carbocation stability
- reaction summary (addition reactions, orientation of addition and carbocation stability)

Alkynes
- addition reactions

Aromatic Compounds
- benzene: aromaticity, resonance
- electrophilic aromatic substitution
- compare to alkenes

Organic Mechanisms & Molecular Orbitals
4
Alcohols
- structure of alcohols, phenols and ethers
- H-bonding and physical properties of alcohols
- acid-base reactions of alcohols & phenols: resonance stabilisation and stability of conjugate base
-oxidation reactions
-elimination reactions and Zaitsev's rule

Amines
- structure of amines
- H-bonding and physical properties of amines
- amines as bases

Introduction to Synthetic Strategies

Stereochemistry
- stereogenic centres
- optical activity
- (R), (S) nomenclature
5

Stereochemistry continued
- racemic mixtures
- compounds with 2 stereogenic centres
- importance of chirality in nature and drug design

Organic Halogen Compounds
- substitiution reactions and scope
- SN1 and SN2 mechanisms: compare carbocation stability and steric hindrance
- consequences of stereochemistry
- elimination reactions
- Grignard formation
6

Aldehydes and Ketones
- structure and polatiry
- nucleophilic addition reactions of Grignard reagents and hydride reducing agents
- oxidation of aldehydes

Carboxylic Acids and Derivatives
- carboxylic acids
- acidity and resonance stabilisation of conjugate base
- reduction to primary alcohols
- formation of acid chlorides
- derivatives (acid halides, anhydrides, esters and amides)
7

Carboxylic Acids and Derivatives Continued
- acid halides, anhydrides, esters & amides
- relative reactivity of carboxylic acid derivatives
- interconversion and hydrolysis of derivatives
- acyl substitution mechanism
- polymers and example of nylon66

Synthetic Strategies
- design of target molecules
- protecting groups
- problem solving
8

Strong Acids and Bases
- electrolytes - strong and weak
- autoionisation of water
- conjugate acid-base pairs

Weak Acids and Bases
- carboxylic acids, carbonic acids, phenols
- ammonia, amines

Calculations Involving pKa
- calculations involving pKa and pKb
- buffers
- common ion effect
9

Periodic Trends in Aqueous Oxides
- acids and bases

Intermolecular Forces and Phase Behaviour
- boiling point trends
- solid structure (ice, etc.)

Physical States and Phase Diagrams
- single component
- enthalpy change
- entropy (qualitative) in gas-liquid equilibrium and endothermicity
- trends in elemental freezing and boiling points
10

Phase Diagrams (2 Components)
- water/salt equilibrium, saturated solutions
- alloys
- miscibility

Crystal Structures
11

Solubility Equilibrium
- calculations involving Ksp
- solubility trends as a function of polarity of solvents (e.g. alcohols in water)
- solubility of ionic solids
- role of intermolecular forces in solubility
- heats of solvation

Hydrolysis of Metal Ions
- introduction ot the ligand bond
12

Metals in Biology
- introduction to transition metals

Coordination Chemistry
- complexes
- cis/trans
- oxidation states
- colour
13

Kinetics
- variability of reaction rates
- review of 1st order rate constants from nuclear chemistry and introduction to 2nd order rate constants
- mechanism and rate determining steps

Kinetics - Influences
- temperature and the Arrhenius relation
- diffusion constants
- solvent polarity

Kinetics - Catalysis
- altering the mechanism
- industrial example
- enzymes
 



Textbook


Blackman, Bottle, Schmid, Mocerino and Wille,
     Chemistry and SI Chemical Data (package), 2nd Edition, 2012 (John Wiley) ISBN: 9781118234228


Textbook resources, including the answers to the odd-numbered problems and the web address for the publisher's site, are available via "Textbook Resources" on USYD eLearning.


Contact Us | Privacy | ©2014 School of Chemistry | last modified Friday, 21 February, 2014 :: top of the page ::